Oxygen minimum zones (also called as the dead zones or hypoxic zones), have been reported for over 400 geographical regions of the World Ocean and regional seas. The phenomenon is a key stressor of open ocean and coastal ecosystems worldwide. In this regard, hypoxic zones became a serious environmental challenge to fishery management. As one of the most prominent oxygen depletions of the ocean, the Arabian Sea oxygen minimum zone extends from the central part of the basin to the coasts of Oman, Iran, Pakistan and India and makes fisheries vulnerable to the shelf hypoxia. Shelf oxygen depletion causes numerous fish kill incidents along the Omani coast. However, the scenario of long-term changes of the shelf oxygen minimum zones and its impact on fish catches are still poorly investigated.